A team of researchers from Pennsylvania State University has developed an algorithm that locates particular topologically associating domains (TADs) which are implicated in disease development, including cancer. The technology, called OnTAD, can monitor the internal architectures of TADs, which are crucial in illustrating their biological roles. Researchers discovered that the division of TADs can expose genes to improper regulatory elements and can lead to unusual gene expression, causing the beginning of cancer. The outcomes prove that OnTAD is an efficacious tool for unveiling various levels of DNA organization across a genome.
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