Astronauts aboard the International Space Station are carrying out some remarkable experiments and one of the most unusual ones uses 3D bioprinters to build organ-like structures in space. As printing complex structures inside organs has proven troublesome in Earth’s gravity so the idea of printing them in microgravity could be a way to conquer those challenges. Scientists use scaffolds to implement a surface for cells to attach based on a proposed firm shape. These practices could help researchers optimize tissue development for use in basic science, personalized medicine, and organ transplantation and advance the production of artificial organs that are used for examining drugs and medications on Earth.