T cells play a major role in the immune system and their overworking can lead to autoimmune diseases such as lymphomas, leukemia, and autoimmune disorders. Now, Yale researchers have found the key factors that play a major role in maintaining the quiet phase of T cell cycling. Researchers found that transcription factors BTG1 and BTG2 act as cellular barriers to reduce the amount of messenger RNA (mRNA), that contains instructions for the formation of T-cells. Researchers hope increasing these key factors might help prevent hyper-activation of T cells, which leads to cancer and autoimmune diseases.