Scientists from Pennsylvania State University have developed a tool that enables them to examine specific DNA structures known as topologically associating domains (TADs) which are connected to the progress of the disease. The newly designed algorithm promptly locates and helps to interpret the complex functions of TADs. Termed the optimized nested TAD (OnTAD), the team’s computational algorithm quickly recognizes the locations of TADs in the genome and allows examination of their internal architectures, essential for understanding their biological functions. These outcomes prove that OnTAD is a compelling tool for unveiling different levels of DNA organization across a genome.